Sensorimotor gating deficit in a developmental model of schizophrenia in male Wistar rats

Farinaz Nasirinezhad, Mohammad Mostofi, Ali Shahbazi

Abstract


Background: Isolation rearing is a neurodevelopmental manipulation that produces behavioral alterations in rodents that in many ways are consistent with resemble schizophrenia. Alteration in sensorimotor gating function has been seen in post-weaning social isolation rearing model of schizophrenia. Pre pulse inhibition (PPI) response is one of the reliable tests for investigation of sensorimotor gating deficits. Genetically variation has been seen in PPI test in rodent models of schizophrenia. The aim of this study is to investigate the sensorimotor deficit in developmental models of schizophrenia in male Wistar rats.

Method: Male Wistar rats (25 days old) were randomly allocated to isolated and social experimental groups. Isolated rats were kept individually per cage, while in social groups 3-4 rats were housed in each cage for eight weeks. On the eighth week sensorimotor deficit was determined in both social and isolated groups via PPI test. Three different pulse intensities were used as pre-pulse.  PPI data were analyzed via repeated measures ANOVA across startle and pre-pulse intensities. One-way ANOVA was performed for each of the pre-pulse intensities followed by Tukey post-hoc.

Results: Isolation-reared rats showed sensorimotor gating deficits, reflected by decreased pre-pulse inhibition of the startle response compared with social rats (P<0.0001). This difference was observed in all three different intensities.

Conclusion: According to the results, we concluded that isolation rearing constitutes a valuable, noninvasive manipulation for modeling schizophrenia-like deficits in male rats. 


Keywords


Schizophrenia; sensory gating; genetic; models, animal; developmental disabilities developmental model

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References


Saperstein AM, Kurtz MM. Current Trends in the Empirical Study of Cognitive Remediation for Schizophrenia. Can J Psychiatry. 2013;58(6):311-8.

Lyon L, Saksida LM, Bussey TJ. Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models. Psychopharmacology (Berl). 2011;220(4):647-72.

Fone KCF, Porkess MV. Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders. Neurosci Biobehav Rev. 2008;32(6):1087-102.

Möller M, Du Preez JL, Emsley R, Harvey BH. Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration. Eur Neuropsychopharmacol. 2011;21(6):471-83.

García-Sánchez F, Martínez-Gras, Rodríguez-Jiménez R, Rubio G. Prepulse inhibition of the startle response/reflex in neuropsychiatric disorders. Rev Neurol. 2011;53(7):422-32 [In Spanish].

Alkondon M, Pereira EFR, Potter MC, Kauffman FC, Schwarcz R, Albuquerque EX. Strain-Specific Nicotinic Modulation of Glutamatergic Transmission in the CA1 Field of the Rat Hippocampus: August Copenhagen Irish Versus Sprague-Dawley. J Neurophysiol. 2006;97(2):1163-70.

Geyer MA, Krebs-Thomson K, Braff DL, Swerdlow NR. Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology (Berl). 2001;156(2-3):117-54.

Faraday MM, O’Donoghue VA, Grunberg NE. Effects of Nicotine and Stress on Startle Amplitude and Sensory Gating Depend on Rat Strain and Sex. Pharmacol Biochem Behav. 1999;62(2):273-84.

Graham FK. The More or Less Startling Effects of Weak Prestimulation. Psychophysiology. 1975;12(3):238-48.

Suárez J, Rivera P, Llorente R, Romero-Zerbo SY, Bermúdez-Silva FJ, de Fonseca FR, et al. Early maternal deprivation induces changes on the expression of 2-AG biosynthesis and degradation enzymes in neonatal rat hippocampus. Brain Res. 2010;1349:162-73.

Grillon C, Falls WA, Ameli R, Davis M. Safety signals and human anxiety: A fear-potentiated startle study. Anxiety. 1994;1(1):13-21.

Braff DL. Gating and Habituation of the Startle Reflex in Schizophrenic Patients. Arch Gen Psychiatry. 1992;49(3):206.

Swerdlow NR, Caine SB, Braff DL, Geyer MA. The neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implications. J Psychopharmacol. 1992;6(2):176-90.

Chester JA, Barrenha GD. Acoustic Startle at Baseline and During Acute Alcohol Withdrawal in Replicate Mouse Lines Selectively Bred for High or Low Al cohol Preference. Alcohol Clin Exp Res. 2007;31(10):1633-44.

Vandergriff J, Kallman MJ, Rasmussen K. Moxonidine, a selective imidazoline-1 receptor agonist, suppresses the effects of ethanol withdrawal on the acoustic startle response in rats. Biol Psychiatry. 2000;47(10):874-9.

Swerdlow NR, Geyer MA. Using an Animal Model of Deficient Sensorimotor Gating to Study the Pathophysiology and New Treatments of Schizophrenia. Schizophr Bull. 1998;24(2):285-301.

Bullock AE, Slobe BS, Vázquez V, Collins AC. Inbred mouse strains differ in the regulation of startle and prepulse inhibition of the startle response. Behav Neurosci. 1997;111(6):1353-60.

Ralph RJ. Dopamine D1 and D2 Agonist Effects on Prepulse Inhibition and Locomotion: Comparison of Sprague-Dawley Rats to Swiss-Webster, 129X1/SvJ, C57BL/6J, and DBA/2J Mice. J Pharmacol Exp Ther. 2004;312(2):733-41.

Swerdlow NR, Shoemaker JM, Auerbach PP, Pitcher L, Goins J, Platten A. Heritable differences in the dopaminergic regulation of sensorimotor gating. Psychopharmacology (Berl). 2003;174(4):452-62.

Swerdlow NR, Light GA, Cadenhead KS, Sprock J, Hsieh MH, Braff DL. Startle Gating Deficits in a Large Cohort of Patients With Schizophrenia. Arch Gen Psychiatry. 2006;63(12):1325-35.

Castellanos FX, Fine EJ, Kaysen D, Marsh WL, Rapoport JL, Hallett M. Sensorimotor gating in boys with Tourette's syndrome and ADHD: Preliminary results. Biol Psychiatry. 1996;39(1):33-41.

Weber M, Swerdlow N. Rat strain differences in startle gating-disruptive effects of apomorphine occur with both acoustic and visual prepulses. Pharmacol Biochem Behav. 2008;88(3):306-11.


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