Review of cell therapy in spinal cord injury; effect on neuropathic pain

Mahmoud Yousefifard, Farinaz Nasirinezhad


Neuropathic pain is a type of chronic pain, which manifests following injury of peripheral or central nervous system. Spinal cord injury is one of the most important etiologies of neuropathic pain. Therefore, to eliminate this pain, repairing the injured site is essential. Currently, using stem cells is a promising method for treating neurodegenerative diseases. Numerous studies are being carried out to extend the duration of life and efficiency of these cells and even genetically guide them to a specific pathway, which has increased hope for treatment of diseases related to the nervous system. In this study, we aim to do a comprehensive review on cell therapy techniques in treatment of neuropathic pain after spinal cord injury.

Neuropathic pain is a type of chronic pain, which manifests following injury of peripheral or central nervous system. Spinal cord injury is one of the most important etiologies of neuropathic pain. Therefore, to eliminate this pain, repairing the injured site is essential. Currently, using stem cells is a promising method for treating neurodegenerative diseases. Numerous studies are being carried out to extend the duration of life and efficiency of these cells and even genetically guide them to a specific pathway, which has increased hope for treatment of diseases related to the nervous system. In this study, we aim to do a comprehensive review on cell therapy techniques in treatment of neuropathic pain after spinal cord injury.


Neuropathic pain; Stem Cells; Cell Therapy; Spinal Cord Injury

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Saffarpour S, Shaabani M, Naghdi N, Farahmandfar M, Janzadeh A, Nasirinezhad F. In vivo evaluation of the hippocampal glutamate, GABA and the BDNF levels associated with spatial memory performance in a rodent model of neuropathic pain. Physiol Behav. 2017;175:97-103.

Woolf CJ, Mannion RJ. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet. 1999;353(9168):1959-64.

Finnerup NB, Otto M, McQuay HJ. Algorithm for neuropathic pain treatment: An evidence based proposal. Pain. 2005;118:289 –305.

Backonja MM, Irving GA, Argoff C. Rational multidrug therapy in the treatment of neuropathic pain. Curr Pain Headache Rep. 2006;10:34-8.

Marineo G, Iorno V, Gandini C, Moschini V, Smith TJ. Scrambler therapy may relieve chronic neuropathic pain more effectively than guideline-based drug management: Results of a pilot, randomized, controlled trial. J Pain Symptom Manage. 2012;43(1):87-95.

Hosseini M, Yousefifard M, Aziznejad H, Nasirinezhad F. The effect of bone marrow–derived mesenchymal stem cell transplantation on allodynia and hyperalgesia in neuropathic animals: a systematic review with meta-analysis. Biol Blood Marrow Transplant. 2015;21(9):1537-44.

Nasirinezhad F, Hosseini M, Karami Z, Yousefifard M, Janzadeh A. Spinal 5-HT3 receptor mediates nociceptive effect on central neuropathic pain; possible therapeutic role for tropisetron. J Spinal Cord Med. 2016;39(2):212-9.

Yousefifard M, Nasirinezhad F, Manaheji HS, Janzadeh A, Hosseini M, Keshavarz M. Human bone marrow-derived and umbilical cord-derived mesenchymal stem cells for alleviating neuropathic pain in a spinal cord injury model. Stem Cell Res Ther. 2016;7(1):36.

Yousefifard M, Rahimi-Movaghar V, Nasirinezhad F, Baikpour M, Safari S, Saadat S, et al. Neural stem/progenitor cell transplantation for spinal cord injury treatment; A systematic review and meta-analysis. Neuroscience. 2016;322:377-97.

Amini N, Vousooghi N, Hadjighassem M, Bakhtiyari M, Mousavi N, Safakheil H, et al. Efficacy of Human Adipose Tissue-Derived Stem Cells on Neonatal Bilirubin Encephalopathy in Rats. Neurotox Res. 2016;29(4):514-24.

Faghihi F, Mirzaei E, Sarveazad A, Ai J, Ebrahimi Barough S, Lotfi A, et al. Differentiation potential of human bone marrow mesenchymal stem cells into motorneuron-like cells on electrospun gelatin membrane. J Mol Neurosci. 2015;55(4):845-53.

Sarvandi SS, Joghataei MT, Parivar K, Khosravi M, Sarveazad A, Sanadgol N. In vitro differentiation of rat mesenchymal stem cells to hepatocyte lineage. Iranian journal of basic medical sciences. 2015;18(1):89-97.

Sarveazad A, Bakhtiari M, Babahajian A, Janzade A, Fallah A, Moradi F, et al. Comparison of human adipose-derived stem cells and chondroitinase ABC transplantation on locomotor recovery in the contusion model of spinal cord injury in rats. Iranian journal of basic medical sciences. 2014;17(9):685-93.

Sarveazad A, Newstead GL, Mirzaei R, Joghataei MT, Bakhtiari M, Babahajian A, et al. A new method for treating fecal incontinence by implanting stem cells derived from human adipose tissue: preliminary findings of a randomized double-blind clinical trial. Stem Cell Res Ther. 2017;8(1):40.

Sohrabi Akhkand S, Amirizadeh N, Nikougoftar M, Alizadeh J, Zaker F, Sarveazad A, et al. Evaluation of umbilical cord blood CD34+ hematopoietic stem cells expansion with inhibition of TGF-beta receptorII in co-culture with bone marrow mesenchymal stromal cells. Tissue Cell. 2016;48(4):305-11.

Babahajian A, Shamseddin J, Sarveazad A. Stem cell therapy in fecal incontinence: a narrative review. J Med Physiol. 2017;2(1):2-9.

Sarveazad A, Babahajian A, Bakhtiari M, Soleimani M, Behnam B, Yari A, et al. The combined application of human adipose derived stem cells and Chondroitinase ABC in treatment of a spinal cord injury model. Neuropeptides. 2017;61:39-47.

Orozco L, Soler R, Morera C, Alberca M, Sanchez A, Garcia-Sancho J. Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot study. Transplantation. 2011;92(7):822-8.

Sandkühler J. Models and mechanisms of hyperalgesia and allodynia. Physiol Rev. 2009;89(2):707-58.

Wang Y, Guo Q, Wang M, Wang E, Zou W, Zhao J. Effect of intrathecal sufentanil and protein kinase C inhibitor on pain threshold and the expression of NMDA receptor/CGRP in spinal dorsal horn in rats with neuropathic pain]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012;37(8):783-9. [Chinese].

Yuan Z, Gong S, Luo J, Zheng Z, Song B, Ma S, et al. Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis. Mol Cell Biol. 2009;29(9):2431-42.

Maione S, Siniscalco D, Galderisi U, de Novellis V, Uliano R, Di Bernardo G, et al. Apoptotic genes expression in the lumbar dorsal horn in a model neuropathic pain in rat. Neuroreport. 2002;13(1):101.

Stemkowski PL, Smith PA. Sensory Neurons, Ion Channels, Inflammation and the Onset of Neuropathic Pain. Can J Neurol Sci. 2012;39(4):416-35.

Vink S, Alewood P. Targeting voltage‐gated calcium channels: developments in peptide and small molecule inhibitors for the treatment of neuropathic pain. Br J Pharmacol. 2012;167(5):970-89.

Liang Y, Jiang W, Zhang Z, Yu J, Tao L, Zhao S. Behavioral and Morphological Evidence for the Involvement of Glial Cells in the Antinociceptive Effect of Najanalgesin in a Rat Neuropathic Pain Model. Biol Pharm Bull. 2012;35(6):850-4.

Hama A, Sagen J. Behavioral characterization and effect of clinical drugs in a rat model of pain following spinal cord compression. Brain Res. 2007;1185:117-28.

Ramer LM, Au E, Richter MW, Liu J, Tetzlaff W, Roskams AJ. Peripheral olfactory ensheathing cells reduce scar and cavity formation and promote regeneration after spinal cord injury. J Comp Neurol. 2004;473(1):1-15.

Yazdani SO, Pedram M, Hafizi M, Kabiri M, Soleimani M, Dehghan MM, et al. A comparison between neurally induced bone marrow derived mesenchymal stem cells and olfactory ensheathing glial cells to repair spinal cord injuries in rat. Tissue Cell. 2012;44(4):205-13.

Oudega M. Molecular and cellular mechanisms underlying the role of blood vessels in spinal cord injury and repair. Cell Tissue Res. 2012;349(1):269-88.

Popovich PG. Building Bridges for Spinal Cord Repair. Cell. 2012;150(6):1105-6.

Deumens R, Koopmans GC, Joosten EAJ. Regeneration of descending axon tracts after spinal cord injury. Prog Neurobiol. 2005;77(1-2):57-89.

Ghosh M, Tuesta LM, Puentes R, Patel S, Melendez K, El Maarouf A, et al. Extensive cell migration, axon regeneration, and improved function with polysialic acid‐modified Schwann cells after spinal cord injury. Glia. 2012;60(6):979–92.

Wolfe D, Mata M, Fink DJ. Targeted Drug Delivery to the Peripheral Nervous System using Gene Therapy. Neurosci Lett. 2012;527:85-9.

Siniscalco D, Rossi F, Maione S. Molecular approaches for neuropathic pain treatment. Curr Med Chem. 2007;14(16):1783-7.

Xu T, Chen M, Zhou Q, Xue Y, Wang L, De Arce VJB, et al. Antisense oligonucleotide knockdown of mGlu5 receptor attenuates the antinociceptive tolerance and up-regulated expression of spinal protein kinase C associated with chronic morphine treatment. Eur J Pharmacol. 2012;683(1-3):78–85.

Mousa SA, Shaqura M, Khalefa BI, Zöllner C, Schaad L, Schneider J, et al. Rab7 Silencing Prevents μ-Opioid Receptor Lysosomal Targeting and Rescues Opioid Responsiveness to Strengthen Diabetic Neuropathic Pain Therapy. Diabetes. 2013;62(4):1308-19.

Gum RJ, Wakefield B, Jarvis MF. P2X receptor antagonists for pain management: examination of binding and physicochemical properties. Purinergic signal. 2012;8(1):41-56.

Aira Z, Buesa I, Gallego M, del Caño GG, Mendiable N, Mingo J, et al. Time-Dependent Cross Talk between Spinal Serotonin 5-HT2A Receptor and mGluR1 Subserves Spinal Hyperexcitability and Neuropathic Pain after Nerve Injury. J Neurosci. 2012;32(39):13568-81.

Schultz SS. Adult stem cell application in spinal cord injury. Curr Drug Targets. 2005;6(1):63-73.

Liang P, Jin L, Liang T, Liu E, Zhao S. Human neural stem cells promote corticospinal axons regeneration and synapse reformation in injured spinal cord of rats. Chin Med J. 2006;119(16):1331-8.

McLaren A. Ethical and social considerations of stem cell research. Nature. 2001;414(6859):129-31.

Lin CR, Wu PC, Shih HC, Cheng JT, Lu CY, Chou AK, et al. Intrathecal spinal progenitor cell transplantation for the treatment of neuropathic pain. Cell Transplant. 2002;11(1):17-24.

Pallini R, Vitiani LR, Bez A, Casalbore P, Facchiano F, Di Giorgi Gerevini V, et al. Homologous transplantation of neural stem cells to the injured spinal cord of mice. Neurosurgery. 2005;57(5):1014-25.

Sun D, Gugliotta M, Rolfe A, Reid W, McQuiston AR, Hu W, et al. Sustained Survival and Maturation of Adult Neural Stem/Progenitor Cells after Transplantation into the Injured Brain. J Neurotrauma. 2011;28(6):961-72.

Mark Richardson R, Broaddus WC, Holloway KL, Fillmore HL. Grafts of adult subependymal zone neuronal progenitor cells rescue hemiparkinsonian behavioral decline. Brain Res. 2005;1032(1):11-22.

Tarasenko YI, Gao J, Nie L, Johnson KM, Grady JJ, Hulsebosch CE, et al. Human fetal neural stem cells grafted into contusion-injured rat spinal cords improve behavior. J Neurosci Res. 2007;85(1):47-57.

Lee S-T, Chu K, Jung K-H, Kim S-J, Kim D-H, Kang K-M, et al. Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke. Brain. 2008;131(3):616-29.

Bacigaluppi M, Pluchino S, Jametti LP, Kilic E, Kilic Ü, Salani G, et al. Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain. 2009:awp174.

Ottoboni L, De Feo D, Merlini A, Martino G. Commonalities in immune modulation between mesenchymal stem cells (MSCs) and neural stem/precursor cells (NPCs). Immunol Lett. 2015;168(2):228-39.

Lee S-T, Chu K, Park H-K, Jung K-H, Kim M, Lee SK, et al. New Concept of Neural Stem Cell Transplantation: Anti-inflammatory Role. Int J Stem Cells. 2008;1(1):36-42.

Abematsu M, Tsujimura K, Yamano M, Saito M, Kohno K, Kohyama J, et al. Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury. J Clin Invest. 2010;120(9):3255-66.

Amemori T, Romanyuk N, Jendelova P, Herynek V, Turnovcova K, Prochazka P, et al. Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat. Stem Cell Res Ther. 2013;4(3):68.

Bottai D, Madaschi L, Di Giulio AM, Gorio A. Viability-dependent promoting action of adult neural precursors in spinal cord injury. Mol Med. 2008;14(9-10):634-44.

Macias MY, Syring MB, Pizzi MA, Crowe MJ, Alexanian AR, Kurpad SN. Pain with no gain: allodynia following neural stem cell transplantation in spinal cord injury. Exp Neurol. 2006;201(2):335-48.

Nutt SE, Chang EA, Suhr ST, Schlosser LO, Mondello SE, Moritz CT, et al. Caudalized human iPSC-derived neural progenitor cells produce neurons and glia but fail to restore function in an early chronic spinal cord injury model. Exp Neurol. 2013;248:491-503.

Tetzlaff W, Okon EB, Karimi-Abdolrezaee S, Hill CE, Sparling JS, Plemel JR, et al. A systematic review of cellular transplantation therapies for spinal cord injury. J Neurotrauma. 2011;28(8):1611-82.

Klein S, Svendsen CN. Stem cells in the injured spinal cord: reducing the pain and increasing the gain. Nat Neurosci. 2005;8(3):259-60.

Hains B, Johnson K, Eaton M, Willis W, Hulsebosch C. Serotonergic neural precursor cell grafts attenuate bilateral hyperexcitability of dorsal horn neurons after spinal hemisection in rat. Neuroscience. 2003;116(4):1097-110.

Pereira Lopes F, Martin P, Frattini F, Biancalana A, Almeida F, Tomaz M, et al. Double gene therapy with G-CSF and VEGF acts synergistically to improve nerve regeneration and functional outcome after sciatic nerve injury in mice. Neuroscience. 2013;230:184-97.

Klass M, Gavrikov V, Drury D, Stewart B, Hunter S, Denson DD, et al. Intravenous mononuclear marrow cells reverse neuropathic pain from experimental mononeuropathy. Anesth Analg. 2007;104(4):944-8.

Sethe S, Scutt A, Stolzing A. Aging of mesenchymal stem cells. Ageing Res Rev. 2006;5(1):91-116.

Beyer Nardi N, Silva Meirelles L. Mesenchymal stem cells: isolation, in vitro expansion and characterization. Stem Cells. 2006:249-82.

Giordano A, Galderisi U, Marino IR. From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells. J Cell Physiol. 2007;211(1):27-35.

Jori FP, Napolitano MA, Melone MAB, Cipollaro M, Cascino A, Altucci L, et al. Molecular pathways involved in neural in vitro differentiation of marrow stromal stem cells. J Cell Biochem. 2005;94(4):645-55.

Bae JS, Han HS, Youn DH, Carter JE, Modo M, Schuchman EH, et al. Bone Marrow‐Derived Mesenchymal Stem Cells Promote Neuronal Networks with Functional Synaptic Transmission After Transplantation into Mice with Neurodegeneration. Stem Cells. 2007;25(5):1307-16.

Tehranipour M. Bone marrow stromal cells for the treatment of spinal cord injury in rats. J Biol Sci. 2010;10(1):53-7.

Bai H, Suzuki Y, Noda T, Wu S, Kataoka K, Kitada M, et al. Dissemination and proliferation of neural stem cells on the spinal cord by injection into the fourth ventricle of the rat: a method for cell transplantation. J Neurosci Methods. 2003;124(2):181-7.

Pirhajati Mahabadi V, Tiraih T, Khalatbary A. Central Neuropathic Pain after Graft of Bone Marrow Stromal Cells in the Spinal Cord Contusion of Rat. J Iran Anatomic Sci. 2007;5(19):93-105.

Weissman IL. Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities. Science. 2000;287(5457):1442-6.

Song L, Tuan RS. Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow. FASEB J. 2004;18(9):980-2.

Tao H, Ma DD. Evidence for transdifferentiation of human bone marrow-derived stem cells: recent progress and controversies. Pathology. 2003;35(1):6-13.

Cao F, Feng S. Human umbilical cord mesenchymal stem cells and the treatment of spinal cord injury. Chin Med J. 2009;122(2):225-31.

Wang L, Tran I, Seshareddy K, Weiss ML, Detamore MS. A comparison of human bone marrow–derived mesenchymal stem cells and human umbilical cord–derived mesenchymal stromal cells for cartilage tissue engineering. Tissue Eng Part A. 2009;15(8):2259-66.

Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ, et al. Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells. 2004;22(7):1330-7.

Ma L, Feng X, Cui B, Law F, Jiang X, Yang L, et al. Human umbilical cord Wharton's Jelly-derived mesenchymal stem cells differentiation into nerve-like cells. Chin Med J. 2005;118(23):1987-93.

Weiss ML, Medicetty S, Bledsoe AR, Rachakatla RS, Choi M, Merchav S, et al. Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease. Stem Cells. 2005;24(3):781-92.

Yang CC, Shih YH, Ko MH, Hsu SY, Cheng H, Fu YS. Transplantation of human umbilical mesenchymal stem cells from Wharton's jelly after complete transection of the rat spinal cord. PLoS One. 2008;3(10):e3336.

Ichim TE, Solano F, Lara F, Paris E, Ugalde F, Rodriguez JP, et al. Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report. Int Arch Med. 2010;3:30.

Zhang L, Zhang HT, Hong SQ, Ma X, Jiang XD, Xu RX. Cografted Wharton’s jelly cells-derived neurospheres and BDNF promote functional recovery after rat spinal cord transection. Neurochem Res. 2009;34(11):2030-9.

Kang K, Kim S, Oh Y, Yu J, Kim K, Park H, et al. A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: a case study. Cytotherapy. 2005;7(4):368-73.

Kao CH, Chen SH, Chio CC, Lin MT. Human umbilical cord blood-derived CD34+ cells may attenuate spinal cord injury by stimulating vascular endothelial and neurotrophic factors. Shock. 2008;29(1):49-55.

Zhao ZM, Li HJ, Liu HY, Lu SH, Yang RC, Zhang QJ, et al. Intraspinal transplantation of CD34+ human umbilical cord blood cells after spinal cord hemisection injury improves functional recovery in adult rats. Cell Transplant. 2004;13(2):113-22.

Armson BA. Umbilical cord blood banking: implications for perinatal care providers. J Obstet Gynaecol Can. 2005;27(3):263-90.

Hoffman RM. The hair follicle as a gene therapy target. Nat Biotechnol. 2000;18(1):20-1.

Amoh Y, Li L, Campillo R, Kawahara K, Katsuoka K, Penman S, et al. Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. Proc Natl Acad Sci U S A. 2005;102(49):17734-8.

Petit I, Kesner NS, Karry R, Robicsek O, Aberdam E, Müller F, et al. Induced pluripotent stem cells from hair follicles as a cellular model for neurodevelopmental disorders. Stem Cell Res. 2012;8:134-40.

Esmaeilzade B, Nobakht M, Joghataei MT, Rahbar Roshandel N, Rasouli H, Samadi Kuchaksaraei A, et al. Delivery of Epidermal Neural Crest Stem Cells (EPI-NCSC) to hippocamp in Alzheimer's Disease Rat Model. Iran Biomed J. 2012;16(1):1-9.

Amoh Y, Li L, Katsuoka K, Hoffman RM. Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function. Cell Cycle. 2008;7(12):1865-9.

De Girolamo L, Arrigoni E, Stanco D, Lopa S, Di Giancamillo A, Addis A, et al. Role of autologous rabbit adipose‐derived stem cells in the early phases of the repairing process of critical bone defects. J Orthop Res. 2011;29(1):100-8.

Estes BT, Diekman BO, Gimble JM, Guilak F. Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype. Nat Protoc. 2010;5(7):1294-311.

Ebrahimian T, Pouzoulet F, Squiban C, Buard V, André M, Cousin B, et al. Cell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing. Arterioscler Thromb Vasc Biol. 2009;29(4):503-10.

Ikegame Y, Yamashita K, Hayashi S-I, Mizuno H, Tawada M, You F, et al. Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy. Cytotherapy. 2011;13(6):675-85.

Meyerrose T, Olson S, Pontow S, Kalomoiris S, Jung Y, Annett G, et al. Mesenchymal stem cells for the sustained in vivo delivery of bioactive factors. Adv Drug Deliv Rev. 2010;62(12):1167-74.

Gimble JM, Guilak F, Bunnell BA. Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells. Stem Cell Res Ther. 2010;1(2):19.

Paspala S, Vishwakarma S, Murthy T, Rao T, Khan A. Potential role of stem cells in severe spinal cord injury: current perspectives and clinical data. Stem Cells Cloning. 2012;5:15-27.

Ra JC, Shin IS, Kim SH, Kang SK, Kang BC, Lee HY, et al. Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem cells in animals and humans. Stem Cells Dev. 2011;20(8):1297-308.

Chung JY, Kim W, Im W, Yoo DY, Choi JH, Hwang IK, et al. Neuroprotective effects of adipose-derived stem cells against ischemic neuronal damage in the rabbit spinal cord. J Neurol Sci. 2012;317(1):40-6.

di Summa PG, Kingham PJ, Raffoul W, Wiberg M, Terenghi G, Kalbermatten DF. Adipose-derived stem cells enhance peripheral nerve regeneration. J Plast Reconstr Aesthet Surg. 2010;63(9):1544-52.

Erba P, Mantovani C, Kalbermatten DF, Pierer G, Terenghi G, Kingham PJ. Regeneration potential and survival of transplanted undifferentiated adipose tissue-derived stem cells in peripheral nerve conduits. J Plast Reconstr Aesthet Surg. 2010;63(12):e811-e7.

Arboleda D, Forostyak S, Jendelova P, Marekova D, Amemori T, Pivonkova H, et al. Transplantation of predifferentiated adipose-derived stromal cells for the treatment of spinal cord injury. Cell Mol Neurobiol. 2011;31(7):1113-22.

Oh JS, Park IS, Kim KN, Kim S-H, Ha Y. Transplantation of an adipose stem cell cluster in a spinal cord injury. Neuroreport. 2012;23(5):277-82.

Ryu H-H, Lim J-H, Byeon Y-E, Park J-R, Seo M-S, Lee Y-W, et al. Functional recovery and neural differentiation after transplantation of allogenic adipose-derived stem cells in a canine model of acute spinal cord injury. J Vet Sci. 2009;10(4):273-84.

Oh JS, Kim KN, An SS, Pennant WA, Kim HJ, Gwak S-J, et al. Cotransplantation of mouse neural stem cells (mNSCs) with adipose tissue-derived mesenchymal stem cells improves mNSC survival in a rat spinal cord injury model. Cell Transplant. 2011;20(6):837-49.

Park S-S, Lee YJ, Lee SH, Lee D, Choi K, Kim W-H, et al. Functional recovery after spinal cord injury in dogs treated with a combination of Matrigel and neural-induced adipose-derived mesenchymal Stem cells. Cytotherapy. 2012;14(5):584-97.

Barriga A, Medrano M, De-Juan J, Burgos J. Intravenous infusion of adult adipose tissue stem cells for repairing spinal cord ischaemic lesions. An experimental study on animals. Rev Esp Cir Ortop Traumatol. 2013;57(2):89-94. [Spanish].


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